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EGFR-IN-119
EGFR-IN-119
SKU:QM-0104136
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Product Details
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Description
EGFR-IN-119 (Compound 5l) is an inhibitor for EGFR with an IC50 of 84.3 nM. EGFR-IN-119 inhibits the cytotoxicity in lung cancer cell A549 with an IC50 of 1.34 μM. EGFR-IN-119 downregulates the expressions of EGFR, KRAS, and MAP2K genes, exhibits antioxidant activity through reduction of reactive oxygen species (ROS), and hyperpolarizes the mitochondrial membrane potential[1].
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Molecular Formula
C25H19N5O3S
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Molecular Weight
469.52
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Smiles
COC1=C(C(OC)=CC(C2=NC3=C(N4C2=NC(C#N)=C4/N=C/C5=CSC=C5)C=CC=C3)=C1)OC
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Target
EGFR; p38 MAPK; Ras; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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EGFR-IN-119
EGFR-IN-119 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.