EGFR-IN-12 [CAS 879127-07-8]
EGFR-IN-12 [CAS 879127-07-8]
SKU:QM-0154640-01
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Product Details
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Description
EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity[1][2].
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CAS Number
[879127-07-8]
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Molecular Formula
C21H18F3N5O
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Molecular Weight
413.4
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Smiles
O=C(C1CC1)NC2=CC=CC(NC3=NC=NC(NC4=CC=CC(C(F)(F)F)=C4)=C3)=C2
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Target
Apoptosis; EGFR
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Isoform
EGFR/ErbB1/HER1; ErbB4/HER4
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Concentration
10mM
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Purity
99.6
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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EGFR-IN-12 [CAS 879127-07-8]
EGFR-IN-12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.