EGFR-IN-120
EGFR-IN-120
SKU:QM-0133969
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Product Details
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Description
EGFR-IN-120 (Compound 11eg) is an orally active EGFR inhibitor. EGFR-IN-120 inhibits EGFRL858R/T790M/C797S with an IC50 value of 0.053 μM, and has a relatively weak effect on EGFRWT (IC50: 1.05 μM) . EGFR-IN-120 inhibits the phosphorylation of EGFR and main downstream effectors (STAT3, AKT, and Erk) . EGFR-IN-120 induces cell cycle arrest and cell apoptosis in EGFR mutant cells. EGFR-IN-120 inhibits the proliferation of the NSCLC cells harboring EGFRL858R/T790M/C797S with an IC50 of 0.052 μM[1].
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Molecular Formula
C31H35FN8O2
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Molecular Weight
570.66
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Smiles
FC1=C(C2=CC=C(C=C(C(NC)=O)N3C(C)C)C3=C2)N=C(NC4=CC=C(N5CCN(C)CC5)C(NC(C=C)=O)=C4)N=C1
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Target
Akt; Apoptosis; EGFR; ERK
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Isoform
EGFR/ErbB1/HER1
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Shipping Conditions
Room temperature
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EGFR-IN-120
EGFR-IN-120 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.