EGFR-IN-134
EGFR-IN-134
SKU:QM-0116593
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Product Details
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Description
EGFR-IN-134 (compound 3f), a triazolo[3,4-a]isoquinoline derivative, is a potent EGFR inhibitor with an IC50 of 0.023 µM. EGFR-IN-134 induces apoptosis and necrosis. EGFR-IN-134 initiates cell cycle arrest at the G2/M and pre-G1 phases, downregulates anti-apoptotic protein Bcl2 and upregulates pro-apoptotic proteins: p53, Bax, and caspases 3, 8, and 9. EGFR-IN-134 shows antiproliferative and anticancer activity[1].
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Molecular Formula
C36H30N6O5
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Molecular Weight
626.66
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Smiles
O=C(C1=NN(C2=CC=C([N+]([O-])=O)C=C2)C3N1CCC4=C3C=C(OC)C(OC)=C4)/C=C/C5=CN(C6=CC=CC=C6)N=C5C7=CC=CC=C7
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Target
Apoptosis; Bcl-2 Family; Caspase; EGFR; MDM-2/p53; Necroptosis
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Isoform
Bax; Bcl-2; Caspase 3; Caspase 8; Caspase 9; EGFR/ErbB1/HER1
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Shipping Conditions
Room temperature
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EGFR-IN-134
EGFR-IN-134 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.