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EGFR-IN-140
EGFR-IN-140
SKU:QM-0009373
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Product Details
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Description
EGFR-IN-140 (Compound 31) is the inhibitor for EGFR, that inhibits EGFR wildtype and EGFR L858R/T790M/C797S mutant with Ki of 0.95 nM and 2.1 nM, and inhibits EGFR del19/T790M/C797S in Ba/F3 with an IC50 of 56.9 nM. EGFR-IN-140 exhibits antitumor efficacy in mouse model[1].
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Molecular Formula
C27H37FN8O2
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Molecular Weight
524.63
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Smiles
CN(CC[C@@]12CC[C@H](N3C4=CC(NC5=NC(N6CC[C@@H](OC)[C@@H](F)C6)=NC=C5)=NN4C=C3CC)CC2)C1=O
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1
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Shipping Conditions
Room temperature
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EGFR-IN-140
EGFR-IN-140 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.