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EGFR-IN-144
EGFR-IN-144
SKU:QM-0010234
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Product Details
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Description
EGFR-IN-144 (Compound 4B) exhibits inhibitory activities against EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL) . EGFR-IN-144 exhibits cytotoxicity in multiple cancer cell with GI50 of nanomolare levels. EGFR-IN-144 downregulates the expressions of mTOR, TNF-α, and IL-6, arrests the cell cycle at G1/S phase, and induces apoptosis[1].
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Molecular Formula
C20H17Cl2N3O3
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Molecular Weight
418.27
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Smiles
COC1=CC=C(C=C1OC)/C=C/C(C2=C(N(N=N2)C3=C(Cl)C=C(Cl)C=C3)C)=O
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Target
Apoptosis; EGFR; Interleukin Related; Microtubule/Tubulin; TNF Receptor
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Shipping Conditions
Room temperature
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EGFR-IN-144
EGFR-IN-144 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.