EGFR-IN-151
EGFR-IN-151
SKU:QM-0011158
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Product Details
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Description
EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. EGFR-IN-151 inhibits the proliferation of a variety lung cancer cells (IC50s for NCI-H1781, HCC827, NCI-H3255 and NCI-H1975 is 11.7, 5.19, 7.32 and 1.53 μM, respectively), inhibits the colony formation and migration of H1975, arrests the cell cycle at G1 phase, and induces apoptosis in H1975[1].
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Molecular Formula
C55H59N9O18
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Molecular Weight
1134.11
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Smiles
O=C(O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=C(C(OCC4=CN(CCOCCOCCOCCN5N=NC(C6=CC=CC(NC7=C8C=C(OCCOC)C(OCCOC)=CC8=NC=N7)=C6)=C5)N=N4)=CC(O)=C3)C1)C9=CC(O)=C(O)C(O)=C9
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Target
Apoptosis; EGFR; ERK; STAT
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Shipping Conditions
Room temperature
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EGFR-IN-151
EGFR-IN-151 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.