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EGFR-IN-154
EGFR-IN-154
SKU:QM-0011292
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Product Details
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Description
EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].
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Molecular Formula
C20H21N5O2
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Molecular Weight
363.41
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Smiles
N=C(NC1CC1)C(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OC)=C4
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Target
Akt; EGFR; JNK; p38 MAPK; PERK
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Shipping Conditions
Room temperature
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EGFR-IN-154
EGFR-IN-154 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.