EGFR-IN-156
EGFR-IN-156
SKU:QM-0011572
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Product Details
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Description
EGFR-IN-156 (Compound 7f) is an EGFR inhibitor that also has inhibitory activity against mutations EGFRL858R and EGFRT790M (IC50 values are 0.186, 0.131, and 0.107 μM, respectively) . EGFR-IN-156 has significant anticancer activity against human cancer cell lines HepG-29 (liver cancer), MCF-7 (breast cancer), and HCT-116 (colon cancer) (IC50 values are 1.67, 5.32, and 6.56 μM, respectively) . EGFR-IN-156 inhibits cancer cell proliferation by inducing cell cycle arrest at the G/G1 phase and triggering apoptosis. EGFR-IN-156 shows promise in EGFR-related cancers[1].
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Molecular Formula
C27H26N4O7S
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Molecular Weight
550.58
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Smiles
O=C1NC(C2=CC=C(OCC(N/N=C/C3=CC=C(OS(=O)(CCC)=O)C(OC)=C3)=O)C=C2)=NC4=CC=CC=C41
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Target
Apoptosis; EGFR
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Shipping Conditions
Room temperature
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EGFR-IN-156
EGFR-IN-156 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.