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EGFR-IN-158
EGFR-IN-158
SKU:QM-0010961
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Product Details
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Description
EGFR-IN-158 (compound 12e) is an orally active EGFR inhibitor with an IC50 of 0.22 nM for EGFR (Del19/T790M) . EGFR-IN-158 inhibits phosphorylation and downstream signaling by binding to EGFR, thereby inhibiting the proliferation of tumor cell lines and promoting apoptosis[1].
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Molecular Formula
C27H35ClN8O4S
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Molecular Weight
603.14
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Smiles
C=CC(NC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(NCC)=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
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Target
Apoptosis; EGFR
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Shipping Conditions
Room temperature
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EGFR-IN-158
EGFR-IN-158 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.