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EGFR-IN-159 [CAS 2055746-08-0]
EGFR-IN-159 [CAS 2055746-08-0]
SKU:QM-0010801
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Product Details
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Description
EGFR-IN-159 (compound 12), a dihydropyrimidine, is a potent EGFR inhibitor with an IC50 value of 29.00 nM. EGFR-IN-159 exhibits dose-dependent inhibition against EGFR and HER2. EGFR-IN-159 shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 has no BBB permeation. EGFR-IN-159 shows appreciable anti-cancer activity[1].
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CAS Number
[2055746-08-0]
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Molecular Formula
C21H23N3O5
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Molecular Weight
397.42
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Smiles
OC1=C(OCC)C=C(C2C(C(NC3=C(OC)C=CC=C3)=O)=C(C)NC(N2)=O)C=C1
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1; ErbB2/HER2
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Shipping Conditions
Room temperature
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EGFR-IN-159 [CAS 2055746-08-0]
EGFR-IN-159 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.