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EGFR-IN-165
EGFR-IN-165
SKU:QM-0012763
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Product Details
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Description
EGFR-IN-165 is a potent EGFR inhibitor. EGFR-IN-165 demonstrates superior potency with IC50s of 17.18 and 64.74 nM against EGFRL858R/T790M and EGFRWT; 2.17 and 6.2 μM against NCI-H1975 cells and A431 cells. EGFR-IN-165 significantly inhibits the migration and induces G1 phase cell cycle arrest and cell apoptosis. EGFR-IN-165 can be used for the study of cancers such as non-small cell lung cancer, colorectal cancer, and head and neck squamous cell carcinoma[1].
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Molecular Formula
C26H21N5O5
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Molecular Weight
483.48
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Smiles
COC1=C(C=C2C(N=CN=C2NC3=CC=C(C(C)=C3)C(OC4=NN=C(O4)C5=CC=CC=C5)=O)=C1)OC
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Target
Apoptosis; EGFR
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Shipping Conditions
Room temperature
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EGFR-IN-165
EGFR-IN-165 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.