EGFR-IN-173
EGFR-IN-173
SKU:QM-0013483
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Product Details
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Description
EGFR-IN-173 is an orally active, pan-mutant EGFR tyrosine kinase inhibitor that targets EGFR 19del, L858R/T790M and C797S triple-mutations, potently inhibiting EGFR19del/T790M/C797S with an IC50 of 1.19 nM while showing over 100-fold selectivity for mutant over wild-type EGFR (IC50 = 19.362 μM against WT) . EGFR-IN-173 significantly inhibits cell migration, induces apoptosis in non-small cell lung cancer (NSCLC) cells. EGFR-IN-173 inhibits EGFR phosphorylation and suppresses the downstream pathways (MAPK/ERK, AKT, STAT3) . EGFR-IN-173 exhibits antitumor efficacy in NSCLC and Ba/F3 xenograft models. EGFR-IN-173 can be used for NSCLC research[1].
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Molecular Formula
C28H36ClN8O2P
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Molecular Weight
583.06
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Smiles
CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC(C4=CN(C)N=C4)=C(N(CCN(C)C)C)C=C3OC)=NC=C2Cl)=O
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Target
Akt; Apoptosis; EGFR; ERK; p38 MAPK; STAT
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Shipping Conditions
Room temperature
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EGFR-IN-173
EGFR-IN-173 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.