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EGFR-IN-175
EGFR-IN-175
SKU:QM-0014915
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Product Details
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Description
EGFR-IN-175 is an orally active and selective EGFRL858R/T790M/C797S inhibitor with an IC50 of 18.94 nM. EGFR-IN-175 can induce cell apoptosis and cause G1 phase arrest. EGFR-IN-175 can downregulate p-EGFR, p-AKT, and p-ERK expression. EGFR-IN-175 can be used for the research of cancer, such as lung cancer[1].
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Molecular Formula
C33H38N10O4S2
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Molecular Weight
702.85
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Smiles
O=C1C(C2=CC=CS2)=NC3=CN=C(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)N=C3N1C7=CN(S(=O)(C8CC8)=O)N=C7OC
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Target
Akt; Apoptosis; EGFR; PERK
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Shipping Conditions
Room temperature
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EGFR-IN-175
EGFR-IN-175 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.