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EGFR-IN-45 [CAS 2765560-03-8]
EGFR-IN-45 [CAS 2765560-03-8]
SKU:QM-0066425
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Product Details
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Description
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 μM and 1.6 μM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].
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CAS Number
[2765560-03-8]
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Molecular Formula
C28H23N7O
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Molecular Weight
473.53
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Smiles
NC1=NC(C2=CC=CC=C2)=NC3=C1C(NC4=CC=CC=C43)=NC5=C(C)N(C)N(C6=CC=CC=C6)C5=O
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Target
Apoptosis; CDK; EGFR; Topoisomerase
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Isoform
CDK2; EGFR/ErbB1/HER1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR-IN-45 [CAS 2765560-03-8]
EGFR-IN-45 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.