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EGFR-IN-48 [CAS 2882851-77-4]
EGFR-IN-48 [CAS 2882851-77-4]
SKU:QM-0065316
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Product Details
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Description
EGFR-IN-48 is a potent and orally active EGFR inhibitor with IC50s of 0.193 nM, 0.251 nM, 10.4 nM for EGFRd19/TM/CS, EGFRLR/TM/CS, EGFRWT, respectively. EGFR-IN-48 inhibits the proliferation of BaF3EGFR del19/T790M/C797S and PC-9EGFR del19/T790M/C797S cells with IC50s of 1.526, 66.7 nM, respectively[1].
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CAS Number
[2882851-77-4]
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Molecular Formula
C35H47BrN9O4PS
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Molecular Weight
800.75
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Smiles
CCC1=CC(NC2=NC=C(C(NC3=CC=C4N=CC=NC4=C3P(C)(C)=O)=N2)Br)=C(C=C1N5CCC(CC5)N6CCN(CC6)CCS(C)(=O)=O)OC
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Target
EGFR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR-IN-48 [CAS 2882851-77-4]
EGFR-IN-48 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.