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EGFR-IN-61 [CAS 2890261-81-9]
EGFR-IN-61 [CAS 2890261-81-9]
SKU:QM-0067635
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Product Details
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Description
EGFR-IN-61 (compound 22a) is a potent EGFR kinase inhibitor, with IC50 values of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S), and 743 nM (WT), respectively. EGFR-IN-61 shows antiproliferative activity against A549 and H1975 cell lines, with IC50 values of 2.14 and 1.82 μM, respectively[1].
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CAS Number
[2890261-81-9]
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Molecular Formula
C33H37ClN8O3
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Molecular Weight
629.15
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Smiles
COC1=CC(N(CCN(C)C)C)=C(C=C1NC2=NC(C3=CN(C4=C3C=CC=C4)CCCO)=CC=N2)NC(C5=CC(Cl)=NC=C5)=O
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR-IN-61 [CAS 2890261-81-9]
EGFR-IN-61 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.