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EGFR mutant-IN-1
EGFR mutant-IN-1
SKU:QM-0060741
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Product Details
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Description
EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor with an IC50 of 27.5 nM, while being a significantly less potent for EGFRWT (IC50 >1.0 μM) [1].
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Molecular Formula
C34H39ClFN7O2
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Molecular Weight
632.17
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Smiles
O=C1C(C2=CC=CC(F)=C2Cl)=C(C)C3=CN=C(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)N=C3N1[C@H]6CN(C(CC)=O)CCC6
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Target
EGFR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR mutant-IN-1
EGFR mutant-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.