EGFR T790M/VEGFR-2-IN-1
EGFR T790M/VEGFR-2-IN-1
SKU:QM-0013025
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Product Details
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Description
EGFR T790M/VEGFR-2-IN-1 (Compound 6) is a dual EGFR T790M mutant (IC50=0.26 μM) and VEGFR-2 (IC50=0.95 μM) inhibitor. EGFR T790M/VEGFR-2-IN-1 blocks tumor cell proliferation and angiogenesis signaling pathways. EGFR T790M/VEGFR-2-IN-1 exhibits potent cytotoxicity against multiple cancer cell lines (HCT116, MCF-7, HepG2, A549; IC50=5.35-9.90 μM) . EGFR T790M/VEGFR-2-IN-1 is promising for research of non-small cell lung cancer and solid tumors[1].
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Molecular Formula
C18H15N11O3S
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Molecular Weight
465.45
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Smiles
O=S(C1=CC=C(/N=N/C2=C3N=C(N)C(C#N)=C(C4=CC=CO4)N3N=C2N)C=C1)(/N=C(N)\N)=O
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Target
EGFR; VEGFR
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Isoform
EGFR/ErbB1/HER1; VEGFR2/KDR/Flk-1
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Shipping Conditions
Room temperature
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EGFR T790M/VEGFR-2-IN-1
EGFR T790M/VEGFR-2-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.