EGFR/tubulin-IN-1
EGFR/tubulin-IN-1
SKU:QM-0015692
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Product Details
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Description
EGFR/tubulin-IN-1 (Compound 26) is a dual-target inhibitor of EGFR and tubulin. EGFR/tubulin-IN-1 significantly reduces the levels of p-EGFR, p-AKT, and p-ERK in cells, disrupting the microtubule structure of the cells. EGFR/tubulin-IN-1 significantly inhibits the proliferation of H1975 cells and significantly blocks the cells in the G2/M phase. EGFR/tubulin-IN-1 induces the expression of autophagy markers LC3B-II and Beclin-1, while down-regulating the expression of p62. EGFR/tubulin-IN-1 induces ferroptosis, with increased ROS content and depletion of glutathione (GSH) . EGFR/tubulin-IN-1 inhibits epithelial-mesenchymal transition (EMT) and tumor metastasis. EGFR/tubulin-IN-1 has a significant tumor-suppressing effect in the H1975 transplanted tumor nude mouse model. EGFR/tubulin-IN-1 can be used for the study of non-small cell lung cancer[1].
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Molecular Formula
C40H43ClFN5O6
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Molecular Weight
744.25
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Smiles
O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1)CCCCCCC(NC4=CC(CCC5=CC(OC)=C(OC)C(OC)=C5)=CC=C4OC)=O
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Target
Akt; Atg8/LC3; Autophagy; EGFR; ERK; Ferroptosis; Microtubule/Tubulin; p62; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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EGFR/tubulin-IN-1
EGFR/tubulin-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.