Emavusertib (hydrochloride) [CAS 2376399-42-5]
Emavusertib (hydrochloride) [CAS 2376399-42-5]
SKU:QM-0062655
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Product Details
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Description
Emavusertib hydrochloride (CA-4948 tosylate) is the hydrochloride salt form of Emavusertib. Emavusertib hydrochloride is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib hydrochloride inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib hydrochloride exhibits antitumor activity in mouse model[1][2][3].
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CAS Number
[2376399-42-5]
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Molecular Formula
C24H26ClN7O5
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Molecular Weight
527.96
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Smiles
O=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=C(N4CC[C@H](C4)O)N=C5C(OC(N6CCOCC6)=N5)=C3.Cl
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Target
Apoptosis; FLT3; IRAK; MyD88; NF-κB
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Isoform
IRAK4
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Emavusertib (hydrochloride) [CAS 2376399-42-5]
Emavusertib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.