Emavusertib (tosylate) [CAS 2376399-41-4]
Emavusertib (tosylate) [CAS 2376399-41-4]
SKU:QM-0006192
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Product Details
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Description
Emavusertib tosylate (CA-4948 tosylate) is the tosylate salt form of Emavusertib. Emavusertib tosylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib tosylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib tosylate exhibits antitumor activity in mouse model[1][2][3].
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CAS Number
[2376399-41-4]
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Molecular Formula
C31H33N7O8S
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Molecular Weight
663.7
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Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.O=C(C2=COC(C3=CC=NC(C)=C3)=N2)NC4=C(N5CC[C@H](C5)O)N=C6C(OC(N7CCOCC7)=N6)=C4
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Target
Apoptosis; FLT3; IRAK; MyD88; NF-κB
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Shipping Conditions
Room temperature
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Emavusertib (tosylate) [CAS 2376399-41-4]
Emavusertib (tosylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.