Epacadostat [CAS 1204669-58-8]
Epacadostat [CAS 1204669-58-8]
SKU:QM-0077215-01
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Product Details
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Description
Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1]. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.
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CAS Number
[1204669-58-8]
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Molecular Formula
C11H13BrFN7O4S
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Molecular Weight
438.23
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Smiles
BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1
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Target
Indoleamine 2,3-Dioxygenase (IDO)
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Isoform
IDO1
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Concentration
10mM
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Purity
99.65
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Epacadostat [CAS 1204669-58-8]
Epacadostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.