Epiberberine (chloride) [CAS 889665-86-5]
Epiberberine (chloride) [CAS 889665-86-5]
SKU:QM-0162293-01
Couldn't load pickup availability
Request quote or documents
![Epiberberine (chloride) [CAS 889665-86-5]](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
-
Description
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3].
-
CAS Number
[889665-86-5]
-
Molecular Formula
C20H18ClNO4
-
Molecular Weight
371.81
-
Smiles
COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1.[Cl-]
-
Target
Beta-secretase; Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)
-
Isoform
AChE; BACE1; BChE
-
Concentration
10mM
-
Purity
99.02
-
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)
-
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
-
Shipping Conditions
Room Temperature
-
Hazard Statement
H302, H315, H319, H335
-
Precautions
H302, H315, H319, H335
Related Products
- QM-0144237-01 Pseudooxynicotine-d4 (hydrochloride) [CAS 764661-23-6]
- QM-0162750-01 Reserpine (Standard) [CAS 50-55-5]
- QM-0158319-01 Quinine (hydrochloride dihydrate) (Standard) [CAS 6119-47-7]
- QM-0142695-01 MC-Val-Cit-PAB-vinblastine [CAS 2055896-92-7]
- QM-0162138-01 Piperine (Standard) [CAS 94-62-2]
- QM-0162124-01 Theobromine (Standard) [CAS 83-67-0]
- QM-0158567-01 Homatropine (Bromide) [CAS 51-56-9]
- QM-0158964-01 Theophylline (Standard) [CAS 58-55-9]
- QM-0162751-01 Reserpine-d9 [CAS 84759-11-5]
- QM-0162137-01 Piperine [CAS 94-62-2]
Other industry favorites
- QM-0144237-01 Pseudooxynicotine-d4 (hydrochloride) [CAS 764661-23-6]
- QM-0162750-01 Reserpine (Standard) [CAS 50-55-5]
- QM-0053535 Methscopolamine-d3 Iodide
- QM-0053168 Homodihydrocapsaicin II [CAS 71239-21-9]
- QM-0139009-01 Thiocolchicine [CAS 2730-71-4]
- QM-0204651-01 Scopolamine (hydrobromide trihydrate) [CAS 6533-68-2]
Epiberberine (chloride) [CAS 889665-86-5]
Epiberberine (chloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.