F-14512 (hydrochloride) [CAS 866874-39-7]
F-14512 (hydrochloride) [CAS 866874-39-7]
SKU:QM-0002986
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Product Details
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Description
F-14512 hydrochloride is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 hydrochloride enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 hydrochloride exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 hydrochloride demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 hydrochloride could be used to study breast cancer[1].
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CAS Number
[866874-39-7]
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Molecular Formula
C33H51Cl4N5O8
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Molecular Weight
787.6
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Smiles
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)O)C4=CC(OCO5)=C5C=C4[C@H]([C@@]2([H])CO1)NC(CNCCCNCCCCNCCCN)=O.Cl.Cl.Cl.Cl
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Target
DNA/RNA Synthesis; Topoisomerase
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Shipping Conditions
Room temperature
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F-14512 (hydrochloride) [CAS 866874-39-7]
F-14512 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.