Flumatinib (mesylate) [CAS 895519-91-2]
Flumatinib (mesylate) [CAS 895519-91-2]
SKU:QM-0146524-01
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Product Details
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Description
Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model[1][2].
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CAS Number
[895519-91-2]
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Molecular Formula
C30H33F3N8O4S
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Molecular Weight
658.69
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Smiles
O=C(NC1=CC(NC2=NC=CC(C3=CC=CN=C3)=N2)=C(C)N=C1)C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4.CS(=O)(O)=O
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Target
Bcr-Abl; c-Kit; PDGFR
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Isoform
Abl; PDGFRβ
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Purity
99.8
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Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Flumatinib (mesylate) [CAS 895519-91-2]
Flumatinib (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.