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Furamidine (dihydrochloride) (Standard) [CAS 55368-40-6]

Furamidine (dihydrochloride) (Standard) [CAS 55368-40-6]

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SKU:QM-0003592

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  • Description

    Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride) . This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively) . Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent[1][2][3].

  • CAS Number

    [55368-40-6]

  • Molecular Formula

    C18H18Cl2N4O

  • Molecular Weight

    377.27

  • Smiles

    N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(N)=N)C=C3)O2)C=C1)N.[H]Cl.[H]Cl

  • Target

    Histone Methyltransferase; Parasite; Phosphodiesterase (PDE) ; Reference Standards

  • Shipping Conditions

    Room temperature

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Furamidine (dihydrochloride) (Standard) [CAS 55368-40-6]

Furamidine (dihydrochloride) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.