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Gefitinib-based PROTAC 3 [CAS 2230821-27-7]

Gefitinib-based PROTAC 3 [CAS 2230821-27-7]

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QM-0141007-01

£215.24 GBP
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Product Details

  • Description

    Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].

  • CAS Number

    [2230821-27-7]

  • Molecular Formula

    C47H57ClFN7O8S

  • Molecular Weight

    934.51

  • Smiles

    O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

  • Target

    EGFR; PROTACs

  • Isoform

    EGFR/ErbB1/HER1

  • Purity

    99.98

  • Solubility

    DMSO : ≥ 60 mg/mL

  • Storage Conditions

    4°C (Powder, sealed storage, away from moisture and light)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
5 mgQM-0141007-01
5 mgQM-0141007-01
£215.24/ea		 £0.00
£215.24/ea £0.00
10 mgQM-0141007-02
10 mgQM-0141007-02
£301.50/ea		 £0.00
£301.50/ea £0.00
25 mgQM-0141007-03
25 mgQM-0141007-03
£476.46/ea		 £0.00
£476.46/ea £0.00
50 mgQM-0141007-04
50 mgQM-0141007-04
£690.30/ea		 £0.00
£690.30/ea £0.00
100 mgQM-0141007-05
100 mgQM-0141007-05
£1,009.85/ea		 £0.00
£1,009.85/ea £0.00
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Gefitinib-based PROTAC 3 [CAS 2230821-27-7]

Gefitinib-based PROTAC 3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.