Glibenclamide-13C6
Glibenclamide-13C6
SKU:QM-0007472
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Product Details
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Description
Glibenclamide-13C6 (Glyburide-13C6) is 13C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) [3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
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Molecular Formula
C17 13C6H26ClN3O5S
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Molecular Weight
497.94
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Smiles
ClC1=CC(C(NCCC2=CC=C(S(NC(N[13CH]3[13C][13CH2][13CH2][13CH2][13CH2]3)=O)(=O)=O)C=C2)=O)=C(OC)C=C1
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Target
Autophagy; CFTR; Isotope-Labeled Compounds; Mitochondrial Metabolism; P-glycoprotein; Potassium Channel
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Shipping Conditions
Room temperature
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Glibenclamide-13C6
Glibenclamide-13C6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.