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Glucosylceramide synthase-IN-4 [CAS 2776965-41-2]
Glucosylceramide synthase-IN-4 [CAS 2776965-41-2]
SKU:QM-0073642
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Product Details
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Description
Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].
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CAS Number
[2776965-41-2]
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Molecular Formula
C22H18F5N3O3
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Molecular Weight
467.39
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Smiles
CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1
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Target
Glucosylceramide Synthase (GCS)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Glucosylceramide synthase-IN-4 [CAS 2776965-41-2]
Glucosylceramide synthase-IN-4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.