Glycolithocholic acid 3-sulfate (disodium) [CAS 64936-82-9]
Glycolithocholic acid 3-sulfate (disodium) [CAS 64936-82-9]
SKU:QM-0088446-01
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Product Details
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Description
Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9 and 66.8 μM (absence of Zn2+) and 8 and 8.7 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease[1][2][3].
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CAS Number
[64936-82-9]
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Molecular Formula
C26H41NNa2O7S
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Molecular Weight
557.65
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Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)(O[Na])=O)([H])CC3)C
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Target
GPR39; HIV
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Purity
99.73
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Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Glycolithocholic acid 3-sulfate (disodium) [CAS 64936-82-9]
Glycolithocholic acid 3-sulfate (disodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.