GNF2133 (hydrochloride) [CAS 2561414-57-9]
GNF2133 (hydrochloride) [CAS 2561414-57-9]
SKU:QM-0147761-01
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Product Details
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Description
GNF2133 hydrochloride is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 μM for DYRK1A and GSK3β, respectively. GNF2133 hydrochloride shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 hydrochloride significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 hydrochloride has the potential for the research of type 1 diabetes[1].
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CAS Number
[2561414-57-9]
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Molecular Formula
C24H31ClN6O2
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Molecular Weight
470.99
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Smiles
O=C(N1CCN(CC1)CC)NC2=NC=CC(C3=CN(C4CCOCC4)C5=C3C=CN=C5)=C2.Cl
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Target
DYRK
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Isoform
DYRK1
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Purity
99.86
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Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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GNF2133 (hydrochloride) [CAS 2561414-57-9]
GNF2133 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.