GSK-J4 (hydrochloride) (Standard) [CAS 1797983-09-5]
GSK-J4 (hydrochloride) (Standard) [CAS 1797983-09-5]
SKU:QM-0007713-01
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Product Details
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Description
GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride) . This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1[1][2][3].
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CAS Number
[1797983-09-5]
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Molecular Formula
C24H28ClN5O2
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Molecular Weight
453.96
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Smiles
O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1.Cl
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Target
Histone Demethylase; Reference Standards
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Shipping Conditions
Room temperature
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GSK-J4 (hydrochloride) (Standard) [CAS 1797983-09-5]
GSK-J4 (hydrochloride) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.