GSK484 (hydrochloride) [CAS 1652591-81-5]
GSK484 (hydrochloride) [CAS 1652591-81-5]
SKU:QM-0079390-01
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Product Details
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Description
GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.
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CAS Number
[1652591-81-5]
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Molecular Formula
C27H32ClN5O3
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Molecular Weight
510.03
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Smiles
O=C(N1C[C@H](N)[C@H](O)CC1)C2=CC(OC)=C3C(N=C(C(N4CC5CC5)=CC6=C4C=CC=C6)N3C)=C2.[H]Cl
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Target
Protein Arginine Deiminase
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Concentration
10mM
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Purity
99.48
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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GSK484 (hydrochloride) [CAS 1652591-81-5]
GSK484 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.