Guanidinoethyl sulfonate (Standard) [CAS 543-18-0]
Guanidinoethyl sulfonate (Standard) [CAS 543-18-0]
SKU:QM-0003887-01
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Product Details
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Description
Guanidinoethyl sulfonate (Standard) is the analytical standard of Guanidinoethyl sulfonate. This product is intended for research and analytical applications. Guanidinoethyl sulfonate is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) . Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury[1][2][3].
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CAS Number
[543-18-0]
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Molecular Formula
C3H9N3O3S
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Molecular Weight
167.19
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Smiles
N=C(NCCS(=O)(O)=O)N
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Target
Endogenous Metabolite; Reference Standards
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Purity
99.86
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Storage Conditions
-20°C, sealed storage, away from light and moisture
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H312, H332
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Precautions
H302, H312, H332
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Guanidinoethyl sulfonate (Standard) [CAS 543-18-0]
Guanidinoethyl sulfonate (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.