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Gusacitinib (hydrochloride) [CAS 2228989-14-6]
Gusacitinib (hydrochloride) [CAS 2228989-14-6]
SKU:QM-0057227
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Product Details
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Description
Gusacitinib (ASN-002) hydrochloride is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib hydrochloride rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib hydrochloride can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2].
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CAS Number
[2228989-14-6]
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Molecular Formula
C24H29ClN8O2
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Molecular Weight
496.99
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Smiles
N#CCC1CCN(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C5C(C=NNC5=O)=N2)CC1.[H]Cl
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Target
JAK; Syk
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Gusacitinib (hydrochloride) [CAS 2228989-14-6]
Gusacitinib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.