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GW274150 (dihydrochloride) [CAS 438542-17-7]
GW274150 (dihydrochloride) [CAS 438542-17-7]
SKU:QM-0059999
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Product Details
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Description
GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM) . GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS) . GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation[1][2][3].
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CAS Number
[438542-17-7]
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Molecular Formula
C8H19Cl2N3O2S
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Molecular Weight
292.23
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Smiles
OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl
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Target
NO Synthase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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GW274150 (dihydrochloride) [CAS 438542-17-7]
GW274150 (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.