GW405833 (hydrochloride) [CAS 1202865-22-2]
GW405833 (hydrochloride) [CAS 1202865-22-2]
SKU:QM-0136648-01
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Product Details
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Description
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist. GW405833 has EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values of 16.1 μM and 4772 nM for CB1. GW405833 hydrochloride also exhibits non-competitive CB1 antagonist, exerting its analgesic effect through a CB1 receptor (rather than CB2) dependent mechanism. GW405833 hydrochloride can significantly inhibit the production of cAMP stimulated by Forskolin. GW405833 hydrochloride inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF)[2][3][4][5][6].
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CAS Number
[1202865-22-2]
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Molecular Formula
C23H25Cl3N2O3
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Molecular Weight
483.82
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Smiles
O=C(C1=C(C(Cl)=CC=C1)Cl)N2C3=C(C=C(OC)C=C3)C(CCN4CCOCC4)=C2C.Cl
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Target
Cannabinoid Receptor; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; TNF Receptor
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Isoform
CB1; CB2; HIF-1α; IL-1
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Purity
99.59
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Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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GW405833 (hydrochloride) [CAS 1202865-22-2]
GW405833 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.