H-L-Phe (4-NH-Poc) -OH (hydrochloride) [CAS 2737202-66-1]
H-L-Phe (4-NH-Poc) -OH (hydrochloride) [CAS 2737202-66-1]
SKU:QM-0069660
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Product Details
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Description
H-L-Phe (4-NH-Poc) -OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2 (CO) 8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported[1][2]. H-L-Phe (4-NH-Poc) -OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[2737202-66-1]
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Molecular Formula
C13H15ClN2O4
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Molecular Weight
298.72
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Smiles
OC([C@@H](N)CC1=CC=C(C=C1)NC(OCC#C)=O)=O.Cl
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Target
ADC Linker
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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H-L-Phe (4-NH-Poc) -OH (hydrochloride) [CAS 2737202-66-1]
H-L-Phe (4-NH-Poc) -OH (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.