Halofuginone (hydrobromide) [CAS 64924-67-0]
Halofuginone (hydrobromide) [CAS 64924-67-0]
SKU:QM-0164418-01
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Product Details
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Description
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
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CAS Number
[64924-67-0]
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Molecular Formula
C16H18Br2ClN3O3
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Molecular Weight
495.59
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Smiles
O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.Br
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Target
Calcium Channel; DNA/RNA Synthesis; Parasite; Sodium Channel; TGF-beta/Smad
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Isoform
Plasmodium
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Purity
99.99
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Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 2.6 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H300+H310+H330
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Precautions
H300+H310+H330
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Halofuginone (hydrobromide) [CAS 64924-67-0]
Halofuginone (hydrobromide) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.