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Halofuginone (hydrochloride) (Standard) [CAS 1217623-74-9]

Halofuginone (hydrochloride) (Standard) [CAS 1217623-74-9]

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SKU:QM-0094291

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  • Description

    Halofuginone (hydrochloride) (Standard) is the analytical standard of Halofuginone (hydrochloride) . This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[1][2][3][4][5].

  • CAS Number

    [1217623-74-9]

  • Molecular Formula

    C16H18BrCl2N3O3

  • Molecular Weight

    451.14

  • Smiles

    O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O.Cl

  • Target

    Calcium Channel; DNA/RNA Synthesis; Parasite; Reference Standards; Sodium Channel; TGF-beta/Smad

  • Shipping Conditions

    Room temperature

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Halofuginone (hydrochloride) (Standard) [CAS 1217623-74-9]

Halofuginone (hydrochloride) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.