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HCA/VEGFR-2-IN-4 [CAS 2971782-83-7]

HCA/VEGFR-2-IN-4 [CAS 2971782-83-7]

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SKU:QM-0072032

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  • Description

    HCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC50=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells[1].

  • CAS Number

    [2971782-83-7]

  • Molecular Formula

    C22H23FN6O5S

  • Molecular Weight

    502.52

  • Smiles

    O=C(CN1CCC(CC1)C(N/N=C2C(NC3=C\2C=C(C=C3)F)=O)=O)NC4=CC=C(C=C4)S(=O)(N)=O

  • Target

    Carbonic Anhydrase; VEGFR

  • Solubility

    10 mM in DMSO

  • Shipping Conditions

    Room temperature

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HCA/VEGFR-2-IN-4 [CAS 2971782-83-7]

HCA/VEGFR-2-IN-4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.