HDAC1-IN-11
HDAC1-IN-11
SKU:QM-0014927
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Product Details
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Description
HDAC1-IN-11 (Compound 6) is a HDAC1 inhibitor with an IC50 of 106.6 nM. HDAC1-IN-11 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC1-IN-11 has antitumor activity and sensitizes Etoposide and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC1-IN-11 can be used for chemotherapy of cancers like NSCLC research[1].
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Molecular Formula
C30H26N4O3
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Molecular Weight
490.55
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Smiles
NC1=CC=CC=C1NC(C2=CC=C(C=C2)CN3C(N(C(C4=CC=CC=C43)=O)CCC5=CC=CC=C5)=O)=O
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Target
Apoptosis; Caspase; DNA/RNA Synthesis; HDAC; RAD51
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Isoform
Caspase 3; Caspase 7; Caspase 9; HDAC1; HDAC6
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Shipping Conditions
Room temperature
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HDAC1-IN-11
HDAC1-IN-11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.