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HDAC1-IN-5
HDAC1-IN-5
SKU:QM-0069205
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Quantity
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Product Details
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Description
HDAC1-IN-5 is a potent HDAC1 inhibitor with IC50 values of 15 nM and 20 nM for HDAC1 and HDAC6, respectively. HDAC1-IN-5 can enhance the acetylation of histone H3 and α-tubulin, as well as promote the activation of caspase 3 in cancer cells, thereby inducing apoptosis. HDAC1-IN-5 induces chromatin damage by binding with DNA. HDAC1-IN-5 has strong inhibitory activity against tumor growth in xenograft mice[1].
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Molecular Formula
C20H21N3O2S
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Molecular Weight
367.46
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Smiles
ONC(CCCCCC1=CC=CC(C2=NN=C(C3=CC=CC=C3)S2)=C1)=O
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Target
Apoptosis; Caspase; HDAC; Microtubule/Tubulin
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Isoform
HDAC1; HDAC6
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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HDAC1-IN-5
HDAC1-IN-5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.