HDAC6-IN-67 [CAS 2196247-20-6]
HDAC6-IN-67 [CAS 2196247-20-6]
SKU:QM-0015171
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Product Details
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Description
HDAC6-IN-67 is a selective HDAC6 inhibitor (IC50 = 17.15 nM) that exhibits 19-fold selectivity over HDAC1. HDAC6-IN-67 selectively inhibits HDAC6 by interacting with Ser531 and His614. HDAC6-IN-67 induces apoptosis by inducing the cleavage of caspases 9, 8, 3, and PARP, upregulating Bax expression, and downregulating Bcl-2 expression. HDAC6-IN-67 effectively induces the acetylation of α-tubulin, without affecting histone H3 acetylation in MCF-7/ADR cells. HDAC6-IN-67 can be used for the study of breast cancer[1].
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CAS Number
[2196247-20-6]
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Molecular Formula
C17H15N3O3
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Molecular Weight
309.32
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Smiles
CC1=NC2=C(C(N1CC3=CC=C(C=C3)C(NO)=O)=O)C=CC=C2
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Target
Apoptosis; Bcl-2 Family; Caspase; HDAC; Microtubule/Tubulin
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Shipping Conditions
Room temperature
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HDAC6-IN-67 [CAS 2196247-20-6]
HDAC6-IN-67 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.