ICSN3250 (hydrochloride) [CAS 1561902-79-1]
ICSN3250 (hydrochloride) [CAS 1561902-79-1]
SKU:QM-0003765-01
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Product Details
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Description
ICSN3250 hydrochloride is a halitulin analogue and a mTORC1 inhibitor. ICSN3250 hydrochloride directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 hydrochloride shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 hydrochloride specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 hydrochloride can be used for the study of cancer [1].
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CAS Number
[1561902-79-1]
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Molecular Formula
C31H41ClN4O8
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Molecular Weight
633.13
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Smiles
OC1=CC(C2=CN(C=C2C3=CC([N+]([O-])=O)=C(O)C(O)=C3)CCCN4CCCCCCCCCCCC4)=CC([N+]([O-])=O)=C1O.Cl
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Target
Atg8/LC3; Autophagy; mTOR; p62; Ribosomal S6 Kinase (RSK)
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Shipping Conditions
Room temperature
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ICSN3250 (hydrochloride) [CAS 1561902-79-1]
ICSN3250 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.