Immunoproteasome-IN-2
Immunoproteasome-IN-2
SKU:QM-0015985
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Product Details
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Description
Immunoproteasome-IN-2 is selective immunoproteasome inhibitor with IC50 = 232.3 nM for LMP7, IC50 = 9384.9 nM for β5. Immunoproteasome-IN-2 exhibits ancillary inhibitory activity against LMP2 and MECL-1 subunits. Immunoproteasome-IN-2 demonstrates anti-inflammatory efficacy in a mouse model of arthritis and shows a favorable safety profile in toxicological studies with reduced hepatotoxicity and hematotoxicity. Immunoproteasome-IN-2 has LMP7/β5 selectivity directly correlated with lower systemic toxicity. Immunoproteasome-IN-2 can be employed for research in arthritis[1].
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Molecular Formula
C32H44N4O8
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Molecular Weight
612.71
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Smiles
O=C(N[C@H](C(N[C@H](C(N[C@H](C([C@@]1(OC1)C)=O)CC2=CCCCC2)=O)[C@@H](C3=CC=C(N=C3)OC)O)=O)CO)C45CC(CC5)CC4
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Target
Proteasome
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Shipping Conditions
Room temperature
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Immunoproteasome-IN-2
Immunoproteasome-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.