Imofinostat [CAS 1338320-94-7]
Imofinostat [CAS 1338320-94-7]
SKU:QM-0141135-01
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Product Details
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Description
Imofinostat (ABT-301; MPT0E028) is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Imofinostat has a weak inhibitory effect on HDAC8 (IC50 of 2.5 μM), but no inhibitory effect on HDAC4 (IC50>10 μM) . Imofinostat reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. Imofinostat has a broad-spectrum antitumor activity, including colorectal cancer, B-cell lymphoma, non-small cell lung carcinoma (NSCLC), and pancreatic cancer, while also showing therapeutic potential in non-tumor diseases like emphysema and pulmonary fibrosis[1][2][3][14][5][6].
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CAS Number
[1338320-94-7]
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Molecular Formula
C17H16N2O4S
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Molecular Weight
344.38
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Smiles
O=C(/C=C/C1=CC2=C(C=C1)N(CC2)S(=O)(C3=CC=CC=C3)=O)NO
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Target
Akt; Apoptosis; HDAC
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Isoform
HDAC1; HDAC2; HDAC6; HDAC8
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Purity
99.4
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Imofinostat [CAS 1338320-94-7]
Imofinostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.