IN-1130 (Standard) [CAS 868612-83-3]
IN-1130 (Standard) [CAS 868612-83-3]
SKU:QM-0016481-01
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Product Details
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Description
IN-1130 (Standard) is the analytical standard of IN-1130. This product is intended for research and analytical applications. IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM) . IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis[1][2].
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CAS Number
[868612-83-3]
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Molecular Formula
C25H20N6O
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Molecular Weight
420.47
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Smiles
O=C(N)C1=CC=CC(CC2=NC(C3=NC(C)=CC=C3)=C(C4=CC=C5N=CC=NC5=C4)N2)=C1
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Target
Reference Standards; TGF-β Receptor
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Shipping Conditions
Room temperature
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IN-1130 (Standard) [CAS 868612-83-3]
IN-1130 (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.