Indole-2-carboxylic acid [CAS 1477-50-5]
Indole-2-carboxylic acid [CAS 1477-50-5]
SKU:QM-0161552-01
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Product Details
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Description
Indole-2-carboxylic acid (I2CA) is a competitive antagonist of the glycine site of the NMDA receptor (Ki=15 μM, 5-fluoro-I2CA) and an inhibitor of HIV-1 integrase. Indole-2-carboxylic acid is selective for the glycine site of the NMDA receptor and blocks the enhancement of NMDA receptor by competitively inhibiting the binding of glycine to the NMDA receptor. Indole-2-carboxylic acid can also inhibit the strand transfer activity of HIV-1 integrase by chelating Mg2+ at the active site of integrase and interacting with the hydrophobic cavity. Indole-2-carboxylic acid can be used in the study of neurological diseases (such as stroke, epilepsy) and HIV-1 infection[1][2].
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CAS Number
[1477-50-5]
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Molecular Formula
C9H7NO2
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Molecular Weight
161.16
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Smiles
O=C(C(N1)=CC2=C1C=CC=C2)O
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Target
HIV; HIV Integrase; iGluR
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Isoform
Human Endogenous Metabolite; NMDA Receptor
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Purity
99.97
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Indole-2-carboxylic acid [CAS 1477-50-5]
Indole-2-carboxylic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.